Applicability of [18F]FDG/PET for investigating rosmarinic acid preconditioning efficacy in a global stroke model in mice

Positron emission tomography (PET) is a non-invasive nuclear imaging technique that uses radiotracers to track cell activity. The radiopharmaceutical 18F-fluoro-2-deoxyglucose ([18F] FDG) most commonly used in medicine for the diagnosis of various diseases, including stroke. A stroke serious condition with high mortality and morbidity rates. Rosmarinic acid (RA) promising therapeutic agent exerts neuroprotective effects against neurological diseases. Therefore, this study aimed evaluate applicability [18F]FDG/PET investigating RA case global model mice. facilitates observation ischemia reperfusion injuries brain. Moreover, recovery glucose metabolism three specific brain regions, striatum, superior colliculus, inferior was observed after preconditioning RA. It concluded may be useful assessment treatment response. In addition, long-term longitudinal using biochemical analysis conjunction functional provide further conclusive results regarding effect on cerebral ischemia.